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Leonardo De Mattos

Team Leader - Permanent Researcher
Technologist
Advanced Robotics
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About

Leonardo Serra De Mattos (B.Sc. 1998, M.Sc. 2003, Ph.D. 2007) is a Permanent Researcher and Head of the Biomedical Robotics Laboratory at the Italian Institute of Technology (IIT, Genoa). His research background includes medical robotics, robot-assisted surgery, laser microsurgery, smart medical devices, computer vision, medical image analysis, user interfaces, mixed and augmented reality, biomedical sensors, systems integration, automation, usability analysis, and robotic micro-biomanipulation. Leonardo received his Ph.D. degree in electrical engineering from the North Carolina State University (NCSU, USA), where he worked as research assistant at the Center for Robotics and Intelligent Machines (CRIM) from 2002 until 2007. Since then he has been a researcher at the IIT’s Department of Advanced Robotics.

Dr. De Mattos is currently leading a team of 14 researchers and technicians at IIT and collaborates closely with other institutions, including hospitals and industry. So far, he has been a key player in securing over 20 million Euros for research through externally funded projects. He was the PI and coordinator of the European project µRALP – Micro-Technologies and Systems for Robot-Assisted Laser Phonomicrosurgery, and of the TEEP-SLA project, which was dedicated to the creation of new interfaces and assistive systems for ALS patients. Currently, Leonardo is the PI and coordinator of the European project AIRCARE and of the translational project Robotic Microsurgery. He is also leading the work on robotic devices for intravenous access, pediatric neurosurgery and surgical augmented reality.

Dr. De Mattos has graduated 20 PhD students and is currently supervising another 4 PhD candidates. He is the author or co-author of more than 200 peer-reviewed publications and 9 patents, and has been the chair and main organizer of several international scientific events, including both the 4th and 9th Joint Workshop on New Technologies for Computer/Robot Assisted Surgery (CRAS 2014, CRAS 2019), the IEEE BioRob 2014 Workshop on Robotic Microsurgery and Image-Guided Surgical Interventions, and the IEEE BioRob 2012 Workshop on Robot-Assisted Laryngeal Microsurgery. He is currently serving as Editor for Applied Sciences and IEEE IROS, and as Associated Editor for IEEE Robotics and Automation Letters. Recently, he has served as Guest Editor for IEEE Transactions on Robotics and Bionics, Frontiers in Robotics and AI, Journal of Intelligent & Robotic Systems, Journal of Medical Robotics Research, and for several IEEE flagship conferences.

All Publications
2025
Baldini C., Azam M.A., Thorniley M., Sampieri C., Ioppi A., Peretti G., Mattos L.S.
AI-Assisted Laryngeal Examination System
Lecture Notes in Computer Science, vol. 15199 LNCS, pp. 133-143
Conference Paper Book Series
2025
Baldini C., Migliorelli L., Berardini D., Azam M.A., Sampieri C., Ioppi A., Srivastava R., Peretti G., Mattos L.S.
Improving real-time detection of laryngeal lesions in endoscopic images using a decoupled super-resolution enhanced YOLO
Computer Methods and Programs in Biomedicine, vol. 260
Article Journal
2024
Baldini C., Azam M.A., Sampieri C., Ioppi A., Ruiz-Sevilla L., Vilaseca I., Alegre B., Tirrito A., Pennacchi A., Peretti G., Moccia S., Mattos L.S.
An automated approach for real-time informative frames classification in laryngeal endoscopy using deep learning
European Archives of Oto-Rhino-Laryngology
Article Journal
2024
Neri A., Coduri M., Penza V., Santangelo A., Oliveri A., Turco E., Pizzirani M., Trinceri E., Soriero D., Boero F., Ricci S., Mattos L.S.
A novel affordable user interface for robotic surgery training: design, development and usability study
Frontiers in Digital Health, vol. 6
Article Journal
2024
Li S., Gunalan A., Azam M.A., Penza V., Caldwell D.G., Mattos L.S.
Auto-CALM: Autonomous Computer-Assisted Laser Microsurgery
IEEE Transactions on Medical Robotics and Bionics
Article Journal
Awards and Achievements
2023
Neri A., Penza V., Mattos L.S.
BEST POSTER AWARD for “Comparative Study of Interfaces for Surgical Augmented Reality”
2023
Cheng Z., Mattos L.S.
BEST RESEARCH PAPER RUNNER-UP for “A Novel Intraoperative Force Estimation Method via Electrical Bioimpedance Sensing”
2022
Azam M. A., Sampieri C., Ioppi A., Benzi P., Giordano G., De Vecchi M., Campagnari V., Li S., Guastini L., Paderno A., Moccia S., Piazza C., Mattos L. S., Peretti G.
FIRST PRIZE, “Videomics of the upper aero-digestive tract,” National Congress of the Italian Society of Otorhinolaryngology, SIO 2022, 27 May 2022
2020
Mattos L., Acemoglu A., Caldwell D.
BEST CONFERENCE PAPER AWARD: "5G Telesurgery – Feasibility Experiment and First Public Demo"
2020
Mattos L. S., Acemoglu A.
BEST CONFERENCE PAPER AWARD, “5G Telesurgery – Feasibility Experiment and First Public Demo”, CRAS 2020, September 2020