I have a Master’s degree in Chemistry and a Ph.D. in Chemical Sciences and Technologies focused on the development of analytical GC-MS methods for identification of environmental pollutants in food. I deepened my knowledge in the analytical chemistry field working for five years at the Ligurian Chemical Laboratory of the Experimental Zooprophylactic Institute of Piemonte, Liguria e Valle d’Aosta, where we analyzed food to detect environmental pollutants, heavy metals, histamine, marine biotoxins and additives thus assuring food safety. In 2012 I joined the Analytical Chemistry Lab at IIT and I started to approach the world of Drug Discovery, dealing with in vitro ADME studies. Today, I’m in charge of most of the DMPK screening assays that our Lab performs such as solubility, metabolic stability, plasma protein binding and permeability assays. Moreover, I normally take part in external projects that involve other IIT Centres, universities or companies. I am among the invertors of Italian patent 102021000018455 “Biomarcatori della Malattia di Alzheimer” and I’m a co-author in 23 papers (2 as First).
Phone
			              	+39 010 2896 959
	              			Research center
					              	CCT@Morego
				              			Biografia
	              			Education
	              			
							                Title: Master's degree in Chemistry
							                Institute: University of Genoa
							                Location: Genova
							                Country: Italy
							                From: 2003 To: null
						                
							                Title: Ph. D.  degree in Chemical Sciences and Technologies
							                Institute: University of Genoa
							                Location: Genova
							                Country: Italy
							                From: 2011 To: null
						                
All Publications
	                2023
										Munafo F., Nigro M., Brindani N., Manigrasso J., Geronimo I., Ottonello G., Armirotti A., De Vivo M.
										Computer-aided identification, synthesis, and biological evaluation of DNA polymerase η inhibitors for the treatment of cancer
										European Journal of Medicinal Chemistry, vol. 248
									2023
										Brindani N., Munafo F., Menichetti A., Donati E., Nigro M., Ottonello G., Armirotti A., De Vivo M.
										Design, synthesis, docking, and biochemical characterization of non-nucleoside SARS-CoV-2 RdRp inhibitors
										Bioorganic and Medicinal Chemistry, vol. 80
									2022
										Munafò F., Nigro M., Brindani N., Manigrasso J., Geronimo I., Ottonello G., Armirotti A., De Vivo M.
										Computer-aided identification, synthesis, and biological evaluation of DNA polymerase η inhibitors for the treatment of cancer
										European Journal of Medicinal Chemistry
									
										
											Article
										
										
											Journal
										
										
									
								2022
										Munafo F., Donati E., Brindani N., Ottonello G., Armirotti A., De Vivo M.
										Quercetin and luteolin are single-digit micromolar inhibitors of the SARS-CoV-2 RNA-dependent RNA polymerase
										Scientific Reports, vol. 12, (no. 1)
									2021
										Borgogno M., Savardi A., Manigrasso J., Turci A., Portioli C., Ottonello G., Bertozzi S.M., Armirotti A., Contestabile A., Cancedda L., De Vivo M.
										Design, Synthesis,In VitroandIn VivoCharacterization of Selective NKCC1 Inhibitors for the Treatment of Core Symptoms in down Syndrome
										Journal of Medicinal Chemistry, vol. 64, (no. 14), pp. 10203-10229
									Colleagues of Analytical Chemistry